Preparation of Lactams from Cyclic Anhydrides <i>via N</i> ?Carboxyanhydride Intermediates
نویسندگان
چکیده
The ring contraction-lactamisation of anhydrides upon reaction with trimethylsilylazide in the presence an amine catalyst has been studied. Under controlled conditions, 5,- 6- and 8-membered lactams can be generated from cyclic operationally simple procedure. In case ?-lactams, methodology allows for synthesis challenging systems incompatible usual disconnection involving activated carbonyl group. larger is hampered by inaccessible monomeric anhydride precursors - a problem which circumvented through rigidification. Succinic make N-carboxyanhydrides use polymer chemistry as ?-peptide precursors.
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2021
ISSN: ['1434-193X', '1099-0690']
DOI: https://doi.org/10.1002/ejoc.202100751